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- Title
Effect of adjuvant hyperbaric oxygen on healing of cartilage lesions treated with microfracture: an experimental study in rats.
- Authors
Başcı, Onur; Çimşit, Maide; Zeren, Selva; Sağlıcan, Yeşim; Akgün, Umut; Kocaoğlu, Barış; Başdemir, Gülçin; Karahan, Mustafa
- Abstract
Purpose: The purpose of this experimental study was to investigate the effect of hyperbaric oxygen (HBO2) therapy com-bined with microfracture technique in the treatment of cartilage lesions. Methods: Adult Wistar rats (n=44) were divided into six groups. In Groups A, B, C and D, ICRS* grade 4 cartilage lesions were made on the femoral sulcus of both knees. Lesions were microfractured on the left knees; the right knees had no further procedure. Groups E and F had no surgery. Groups A, C and E received HBO2 therapy once a day, six days a week postoperatively. Groups B, D and F had no HBO2 therapy. The animals in Groups A, B, E and F were sacrificed after two weeks; Groups C and D were sacrificed after four weeks. Semiquantitative scale - including filling of defect (microfracture hole), reparative tissue thickness, cell morphology and subchondral bone maturation - was used for evaluation. The Mann-Whitney test was used to compare individual and total scores. Results: Total scores of the two-week group with adjuvant HBO2 therapy were significantly higher (P=0.0007) than the twoweek standard treatment group. Except for subchondral bone maturation, individual scores were significantly higher in the two-week group with adjuvant HBO2 therapy. Total scores of the four-week groups were similar. Among individual scores of the four-week groups, filling of the defect (microfracture hole), and subchondral bone maturation were significantly higher (P=0.01, P=0.03) in groups with adjuvant HBO2 therapy. Conclusion: Adjuvant HBO2 therapy accelerates the healing process of cartilage lesions treated with microfracture in rats.
- Subjects
HYPERBARIC oxygenation; CARTILAGE injuries; MICROFRACTURE surgery; LABORATORY rats; FEMORAL artery
- Publication
Undersea & Hyperbaric Medicine, 2018, Vol 45, Issue 4, p411
- ISSN
1066-2936
- Publication type
Article
- DOI
10.22462/07.08.2018.5