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- Title
Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults.
- Authors
Sasayama, Daimei; Hori, Hiroaki; Teraishi, Toshiya; Hattori, Kotaro; Ota, Miho; Matsuo, Junko; Kawamoto, Yumiko; Kinoshita, Yukiko; Amano, Naoji; Kunugi, Hiroshi
- Abstract
Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers ( P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.
- Subjects
COGNITIVE ability; INTERLEUKIN-6 receptors; GENETIC polymorphisms; WECHSLER Adult Intelligence Scale; INTELLECT; LONG-term memory; COMPARATIVE studies
- Publication
Journal of Neural Transmission, 2012, Vol 119, Issue 3, p313
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-011-0709-3