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- Title
Demyelinating Activity of Canine Distemper Virus Isolates in Gnotobiotic Dogs.
- Authors
McCullough, Bruce; Krakowka, Steven; Koestner, Adalbert; Shadduckt, John
- Abstract
Demyelination was induced in 16 of 35 gnotobiotic dogs by infection with canine distemper virus from a naturally occurring case of demyelinating distemper. In addition, this infection induced absolute lymphopenia, which persisted for several weeks. Two forms of demyelinating disease occurred after infection. Eleven dogs developed neurological signs several weeks after infection and rapidly became moribund. They remained lymphopenic and had thymic atrophy and generalized lymphoid depletion. Hematogenous mononuclear inflammatory cells were not present in the brains of these dogs. In contrast, demyelination associated with nonsuppurative encephalitis was demonstrated in five of 24 dogs that survived the 12-week observation period. Lymphocyte counts were normal in the 24 surviving dogs by eight weeks after infection. A French strain of canine distemper virus induced demyelination in three of 17 gnotobiotic dogs, while no demyelination occurred in eight dogs inoculated with either Snyder-Hill or glial tissue cultureadapted (Lederle) canine distemper virus.
- Publication
Journal of Infectious Diseases, 1974, Vol 130, Issue 4, p343
- ISSN
0022-1899
- Publication type
Article