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- Title
CHARACTERISTICS OF VACCINE-INDUCED AND NATURAL INFECTION WITH ADENOVIRUS TYPE 4 IN NAVAL RECRUITS1.
- Authors
ROSENBAUM, M. J.; DE BERRY, P.; SULLIVAN, E. J.; EDWARDS, E. A.; PIERCE, W. E.; MULDOON, R. L.; JACKSON, G. G.; PECKINPAUGH, R. O.
- Abstract
Rosenbaum, M. J. (Naval Med. Research Unit No. 4, Great Lakes, III. 60088), P. de Berry, E. J. Sullivan et al. Characteristics of vaccine-induced and natural infection with adenovirus type 4 in naval recruits. ., 1968, 88: 45–54—Laboratory studies of natural and artificially induced adenovirus type 4 infections were carried out at two navy recruit training centers. Virus excretion characteristics of live adenovirus vaccine at Great Lakes were similar to those at San Diego. Almost 90 per cent of vaccinees had evidence of induced infection. Onset of vaccine virus excretion occurred by the third day after immunization; one-half of subjects were infected by day 5. Virus shedding terminated by the third week. There was no indication that vaccine virus spread to cohorts treated with placebo. The vaccine's protective effect in inhibiting suprainfections by wild strains of adenovirus type 4 was demonstrated at both training centers. The protection appeared to be selective against natural infections in the enteric tract more than in the oropharyngeal cavity. Adenovirus neutralizing antibody response was uniformly good in vaccinees with 90 per cent showing seroconversions six weeks after immunization. Complement-fixation responses occurred in only 52 per cent of vaccinees, which may indicate attenuation of the vaccine virus.
- Publication
American Journal of Epidemiology, 1968, Vol 88, Issue 1, p45
- ISSN
0002-9262
- Publication type
Article