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- Title
Role of Lymphovascular Invasion in Oral Cavity Squamous Cell Carcinoma Regional Metastasis and Prognosis.
- Authors
Moore, Abigail E.; Alvi, Sameer A.; Tarabichi, Osama; Zhu, Vivian L.; Buchakjian, Marisa R.
- Abstract
Objective: The overall 5-year survival for oral squamous cell carcinoma (OSCC) has not changed in the last 20 years despite advances in treatment. Lymphovascular invasion (LVI) has been shown to be a negative prognostic factor in other cancers, however its role in the prognosis of OSCC remains unclear. This study aims to determine if LVI is a predictor of cervical lymph node metastasis and/or recurrence in OSCC. Methods: We conducted a retrospective cohort review of patients from our institutional cancer registry who were treated for OSCC between 2004 and 2018. Patient demographics, surgical pathology results, and clinical outcome data were collected. A multivariable logistic regression analysis was performed to determine if LVI was an independent predictor of cervical lymph node metastasis and/or recurrence. Results: 442 patients were included, 32.8% were female and median age at time of diagnosis was 61.2 years. LVI was present in 32.8% of patients. When controlled for age, sex, t-classification, perineural invasion, depth of invasion (DOI), and margin status, LVI was a significant predictor of the presence of cervical node metastasis (OR: 3.42, CI: 2.17-5.39, P <.001). There was no significant association found between LVI and local recurrence (OR: 1.03, CI: 0.57-1.84, P =.92), regional recurrence (OR: 1.10, CI: 0.57-2.11, P =.78), or distant recurrence (OR: 1.59, CI: 0.87-2.94, P =.13). Conclusion: The results of this study suggest that LVI is a significant predictor of the presence of cervical lymph node metastasis at presentation independent of other known prognostic factors. LVI, however, was not found to be a significant independent predictor of locoregional or distant recurrence. Level of Evidence: Level III
- Subjects
UNITED States; CONFIDENCE intervals; CANCER invasiveness; MULTIVARIATE analysis; HEAD &; neck cancer; LYMPH nodes; METASTASIS; RETROSPECTIVE studies; DISEASE relapse; RISK assessment; DESCRIPTIVE statistics; RESEARCH funding; LOGISTIC regression analysis; ODDS ratio; SQUAMOUS cell carcinoma; LONGITUDINAL method; DISEASE risk factors
- Publication
Annals of Otology, Rhinology & Laryngology, 2024, Vol 133, Issue 3, p300
- ISSN
0003-4894
- Publication type
Article
- DOI
10.1177/00034894231211116