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- Title
Influence of inflammatory processes on thalamocortical activity.
- Authors
Rychlik, Nicole; Hundehege, Petra; Budde, Thomas
- Abstract
It is known that the thalamus plays an important role in pathological brain conditions involved in demyelinating, inflammatory and neurodegenerative diseases such as Multiple Sclerosis (MS). Beside immune cells and cytokines, ion channels were found to be key players in neuroinflammation. MS is a prototypical example of an autoimmune disease of the central nervous system that is classified as a channelopathy where abnormal ion channel function leads to symptoms and clinical signs. Here we review the influence of the cytokine-ion channel interaction in the thalamocortical system in demyelination and inflammation.
- Subjects
INFLAMMATION; CENTRAL nervous system diseases; ION channels; THALAMOCORTICAL system; SYMPTOMS; THALAMIC nuclei; MYELIN proteins
- Publication
Biological Chemistry, 2023, Vol 404, Issue 4, p303
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/hsz-2022-0215