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- Title
Early adverse perinatal complications in preterm growth-restricted fetuses.
- Authors
DAMODARAM, Mellisa; STORY, Lisa; KULINSKAYA, Elena; RUTHERFORD, Mary; KUMAR, Sailesh
- Abstract
Growth-restricted fetuses are at increased risk of adverse perinatal outcome when compared to their normally grown counterparts. The additional risks associated with growth restriction in preterm fetuses are not well quantified, and this meta-analysis serves to address this uncertainty. This is a meta-analysis and meta-regression of all relevant studies published since 1997 investigating perinatal outcome in preterm growth-restricted fetuses. Growth-restricted fetuses across all gestational ages were found to be at significant risk of having low Apgar scores at 5 min, sepsis, intracranial haemorrhage, intrauterine and neonatal death, necrotising enterocolitis and respiratory complications. Although this risk reduced as gestation increased, it remained amplified in growth-restricted fetuses when compared to normally grown fetuses. This large meta-analysis for the first time quantifies the additional perinatal risks associated with preterm fetal growth restriction and may help counsel parents about the complications these fetuses face following birth.
- Subjects
APGAR score; BIRTH size; CEREBRAL hemorrhage; CONFIDENCE intervals; NEONATAL necrotizing enterocolitis; FETAL growth retardation; GESTATIONAL age; NEONATAL diseases; PREMATURE infants; EVALUATION of medical care; META-analysis; PERINATAL death; PREGNANCY; SEPSIS
- Publication
Australian & New Zealand Journal of Obstetrics & Gynaecology, 2011, Vol 51, Issue 3, p204
- ISSN
0004-8666
- Publication type
Article
- DOI
10.1111/j.1479-828X.2011.01299.x