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- Title
Synthesis of bipolar tetradentate ligand and determination of fructose 1,6-diphosphate by resonance light scattering of its supramolecular polymer.
- Authors
Li, Zhiyang; Xiao, Xilin; Su, Changlin; Hu, Nan; Nie, Changming; Liu, Yong; Zhang, Di; Wang, Zhimei; Liao, Lifu
- Abstract
In this paper, a novel method was established for determination of fructose 1,6-diphosphate (F-1,6-BP) based on resonance light scattering (RLS), and a type of bipolar tetradentate schiff base H4L was synthesized. The study showed that under the optimization condition with the ligand concentration of 5 nmol mL−1, pH 6.5, the reaction temperature of 25 °C, the reaction time of 30 min, RLS intensity had good linearity with the concentration of F-1,6-BP within the range of 0.4–5.0 nmol mL−1, the limit of detection was 0.16 nmol mL−1 and the relative standard deviation (RSD) was 1.83%. In vitro feasibility study, four groups of medical injections and two groups of human urine were analyzed, the RSD of six parallel experiments was approximately 2%, and the recovery value changed from 98.0 to 102.5%. As shown herein, this method has high sensitivity, good precision and recovery.
- Subjects
SUPRAMOLECULAR polymers; LIGHT scattering; RESONANCE; SCHIFF bases; FRUCTOSE
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2020, Vol 323, Issue 1, p431
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-019-06947-2