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- Title
Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler.
- Authors
Morra, Marco; Giavaresi, Gianluca; Sartori, Maria; Ferrari, Andrea; Parrilli, Annapaola; Bollati, Daniele; Baena, Ruggero Rodriguez Y.; Cassinelli, Clara; Fini, Milena
- Abstract
The paper presents results of physico-chemical and biological investigations of a surface-engineered synthetic bone filler. Surface analysis confirms that the ceramic phosphate granules present a collagen nanolayer to the surrounding environment. Cell cultures tests show that, in agreement with literature reports, surface-immobilized collagen molecular cues can stimulate progression along the osteogenic pathway of undifferentiated human mesenchymal cells. Finally, in vivo test in a rabbit model of critical bone defects shows statistically significant increase of bone volume and mineral apposition rate between the biomimetic bone filler and collagen-free control. All together, obtained data confirm that biomolecular surface engineering can upgrade the properties of implant device, by promoting more specific and targeted implant-host cells interactions.
- Publication
Journal of Materials Science: Materials in Medicine, 2015, Vol 26, Issue 4, p159
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-015-5483-6