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- Title
Exposure to metal fumes and circulating miRNAs in Algerian welders.
- Authors
Amrani, Imene; Haddam, Nahida; Garat, Anne; Allorge, Delphine; Zerimech, Farid; Schraen, Susanna; Taleb, Abdessalam; Merzouk, Hafeda; Edme, Jean-Louis; Lo-Guidice, Jean-Marc
- Abstract
Purpose: A cross-sectional study was conducted in a group of Algerian welders to study the relationship between the exposure to metal particles from welding fumes and the concentration of three circulating miRNAs, miR-21, miR-146a and miR-155, as markers of renal function injury. Methods: Characteristics of the subjects and the curriculum laboris were determined by questionnaires. We measured the concentrations of metals in blood and urine samples using ICP-MS. The three circulating miRNAs studied were measured by quantitative PCR. Associations between miRNAs and internal exposure markers were assessed by simple and multiple regression analyses. Results: miR-21 was significantly lower among welders (p = 0.017), compared with controls, adjusted for age, body mass index, smoking status and seniority. Significant adjusted associations were observed between miR-21 or miR-155 and urinary chromium (p = 0.005 or p = 0.041, respectively), miR-146a and urinary nickel (p = 0.019). The results of the multivariate analysis showed that duration of employment was the main factor responsible for the variation of miRNAs among welders. Conclusion: In conclusion, a recent exposure to certain metals, mainly chromium and nickel, appears to be associated to a decrease in plasma expression of miR-21, miR-146a and miR-155. Further larger studies would help to determine the mechanisms of action of metal particles on miRNA expression.
- Subjects
MICRORNA; WELDING fumes; POISONOUS gases; MULTIPLE regression analysis; BODY mass index; WELDERS (Persons); CHROMIUM in the body
- Publication
International Archives of Occupational & Environmental Health, 2020, Vol 93, Issue 5, p553
- ISSN
0340-0131
- Publication type
Article
- DOI
10.1007/s00420-019-01509-1