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- Title
Synthesis, Analysis, and Acute Toxicity of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2-α]benzimidazole Dinitrate.
- Authors
Mitrakova, D. O.; Chernikov, M. V.; Spasov, A. A.; Morkovnik, A. S.; Remezova, I. P.; Bunyatyan, N. D.; Morosov, A. V.; Divaeva, L. N.; Zhukovskaya, O. N.
- Abstract
The key synthetic stage (cyclization) of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2-α]benzimidazole dinitrate, which possesses antiulcer activity, was improved by changing the reaction medium and using the imine itself rather than its hydrobromide for the cyclization. A method using the physicochemical properties (NMR and IR spectroscopy and UV spectrophotometry) of the substance was proposed for identifying it. An HPLC method was proposed for determining related impurities; nonaqueous titration, for quantitative determination. Acute toxicity was studied in mice and rats upon intragastric and intravenous administration. The results showed that the drug substance had class 3 moderate toxicity upon both intragastric and intravenous administration.
- Subjects
ACUTE toxicity testing; ULTRAVIOLET spectrophotometry; BENZIMIDAZOLES; INTRAVENOUS therapy; NUCLEAR magnetic resonance spectroscopy; HIGH performance liquid chromatography
- Publication
Pharmaceutical Chemistry Journal, 2021, Vol 55, Issue 6, p544
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-021-02457-2