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- Title
Antihypoxic and hemostimulating actions of a nettle extract prepared by a nanotechnological approach.
- Authors
Burkova, V. N.; Boev, S. G.; Vengerovskii, A. I.; Yudina, N. V.; Arbuzov, A. G.
- Abstract
Studies using models of hypobaric and hemic hypoxia in mice and circulatory impairment induced by lead acetate showed that a nettle leaf extract dispersed into nanoparticles increased the survival rate, prolonged the time to death, prevented gastric ulceration, increased blood erythrocyte and leukocyte counts and hemoglobin levels, and decreased prothrombin time, the effects being greater than those obtained with a nettle leaf extract prepared by grinding to a particle size of 1 mm. The antihypoxic action of the nettle leaf extract prepared by nanotechnological methods was as great as the effect of a Rhodiola extract, while the hemostimulatory action was no less than that of ferrous sulfate.
- Subjects
NETTLES; PLANT extracts; NANOPARTICLES; ERYTHROCYTES; LEUCOCYTES; HEMOGLOBINS; HYPOXEMIA; FERROUS sulfate; THERAPEUTICS
- Publication
Pharmaceutical Chemistry Journal, 2010, Vol 44, Issue 3, p141
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-010-0417-6