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- Title
Reversal of o-Nitrobenzoic Acid Inhibition of Microbial Growth by Amino-Acids.
- Authors
KIRKLAND, JERRY J.; DURHAM, NORMAN N.
- Abstract
SEVERAL benzene derivatives reportedly inhibit microbial growth by blocking essential metabolic reactions but, in some instances, the site of inhibition has not been established. High concentrations of p-aminobonzoic acid inhibit certain bacteria1,2 and the bacteriostatic activity toward Escherichia coli strain W is reversed by p-hydroxybenzoic acid and, to a limited extent, by shikimic acid or 5-dehydroshikimic acid1. p-Aminobenzoic acid also suppresses growth of Saccharomyces cerevisiae. which can be reversed by aromatic amino-acids such as phenylalanine, tyrosine and tryptophan3. Utilization of p-aminobenzoic acid as an oxidizable substrate by a Flavobacterium4 is competitively inhibited by p-aminosalicylic acid5, and it has been suggested that p-aminosalicylic acid competes with the substrate for the specific transport mechanism(s)6.
- Publication
Nature, 1963, Vol 197, Issue 4863, p210
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/197210a0