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Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36858-6
By:
- Ravindra, Kodihalli C.;
- Vaidya, Vishal S.;
- Wang, Zhenyu;
- Federspiel, Joel D.;
- Virgen-Slane, Richard;
- Everley, Robert A.;
- Grove, Jane I.;
- Stephens, Camilla;
- Ocana, Mireia F.;
- Robles-Díaz, Mercedes;
- Isabel Lucena, M.;
- Andrade, Raul J.;
- Atallah, Edmond;
- Gerbes, Alexander L.;
- Weber, Sabine;
- Cortez-Pinto, Helena;
- Fowell, Andrew J.;
- Hussaini, Hyder;
- Bjornsson, Einar S.;
- Patel, Janisha
Publication type:
Article
MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis.
Published in:
Journal of Clinical Investigation, 2015, v. 125, n. 3, p. 1069, doi. 10.1172/JCI74347
By:
- Murugaiyan, Gopal;
- da Cunha, Andre Pires;
- Ajay, Amrendra K.;
- Joller, Nicole;
- Garo, A. Lucien P.;
- Kumaradevan, Sowmiya;
- Nir Yosef;
- Vaidya, Vishal S.;
- Weiner, Howard L.
Publication type:
Article
Next-generation biomarkers for detecting kidney toxicity.
Published in:
2010
By:
- Bonventure, Joseph V.;
- Vaidya, Vishal S.;
- Schmouder, Robert;
- Feig, Peter;
- Dieterle, Frank
Publication type:
Opinion
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.
Published in:
Nature Biotechnology, 2010, v. 28, n. 5, p. 478, doi. 10.1038/nbt.1623
By:
- Vaidya, Vishal S.;
- Ozer, Josef S.;
- Dieterle, Frank;
- Collings, Fitz B.;
- Ramirez, Victoria;
- Troth, Sean;
- Muniappa, Nagaraja;
- Thudium, Douglas;
- Gerhold, David;
- Holder, Daniel J.;
- Bobadilla, Norma A.;
- Marrer, Estelle;
- Parentes, Elias;
- Cordier, André;
- Vonderscher, Jacky;
- Maurer, Gérard;
- Goering, Peter L.;
- Sistare, Frank D.;
- Bonventre, Joseph V.
Publication type:
Article
Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function.
Published in:
Kidney International, 2011, v. 79, n. 10, p. 1119, doi. 10.1038/ki.2010.555
By:
- Endre, Zoltán H.;
- Pickering, John W.;
- Walker, Robert J.;
- Devarajan, Prasad;
- Edelstein, Charles L.;
- Bonventre, Joseph V.;
- Frampton, Christopher M.;
- Bennett, Michael R.;
- Qing Ma;
- Sabbisetti, Venkata S.;
- Vaidya, Vishal S.;
- Walcher, Angela M.;
- Shaw, Geoffrey M.;
- Henderson, Seton J.;
- Nejat, Maryam;
- John B. W. Schollum;
- George, Peter M.
Publication type:
Article
Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase.
Published in:
2011
By:
- Vaidya VS;
- Niewczas MA;
- Ficociello LH;
- Johnson AC;
- Collings FB;
- Warram JH;
- Krolewski AS;
- Bonventre JV;
- Vaidya, Vishal S;
- Niewczas, Monika A;
- Ficociello, Linda H;
- Johnson, Amanda C;
- Collings, Fitz B;
- Warram, James H;
- Krolewski, Andrzej S;
- Bonventre, Joseph V
Publication type:
journal article
Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase.
Published in:
Kidney International, 2011, v. 79, n. 4, p. 464, doi. 10.1038/ki.2010.404
By:
- Vaidya, Vishal S.;
- Niewczas, Monika A.;
- Ficociello, Linda H.;
- Johnson, Amanda C.;
- Collings, Fitz B.;
- Warram, James H.;
- Krolewski, Andrzej S.;
- Bonventre, Joseph V.
Publication type:
Article
Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury.
Published in:
Kidney International, 2010, v. 77, n. 8, p. 708, doi. 10.1038/ki.2009.422
By:
- Ferguson, Michael A.;
- Vaidya, Vishal S.;
- Waikar, Sushrut S.;
- Collings, Fitz B.;
- Sunderland, Kelsey E.;
- Gioules, Costas J.;
- Bonventre, Joseph V.
Publication type:
Article
A rapid urine test for early detection of kidney injury.
Published in:
Kidney International, 2009, v. 76, n. 1, p. 108, doi. 10.1038/ki.2009.96
By:
- Vaidya, Vishal S.;
- Ford, Glen M.;
- Waikar, Sushrut S.;
- Yizhuo Wang;
- Clement, Matthew B.;
- Ramirez, Victoria;
- Glaab, Warren E.;
- Troth, Sean P.;
- Sistare, Frank D.;
- Prozialeck, Walter C.;
- Edwards, Joshua R.;
- Bobadilla, Norma A.;
- Mefferd, Stephen C.;
- Bonventre, Joseph V.
Publication type:
Article
Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury.
Published in:
PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0133417
By:
- Chung, Hyun Jung;
- Pellegrini, Kathryn L.;
- Chung, Jaehoon;
- Wanigasuriya, Kamani;
- Jayawardene, Innocent;
- Lee, Kyungheon;
- Lee, Hakho;
- Vaidya, Vishal S.;
- Weissleder, Ralph
Publication type:
Article
Evidence of Uncoupling between Renal Dysfunction and Injury in Cardiorenal Syndrome: Insights from the BIONICS Study.
Published in:
PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0112313
By:
- Legrand, Matthieu;
- De Berardinis, Benedetta;
- Gaggin, Hanna K.;
- Magrini, Laura;
- Belcher, Arianna;
- Zancla, Benedetta;
- Femia, Alexandra;
- Simon, Mandy;
- Motiwala, Shweta;
- Sambhare, Rasika;
- Di Somma, Salvatore;
- Mebazaa, Alexandre;
- Vaidya, Vishal S.;
- JrJanuzzi, James L.;
- (GREAT), from the Global Research on Acute Conditions Team
Publication type:
Article
Heterozygosity for Fibrinogen Results in Efficient Resolution of Kidney Ischemia Reperfusion Injury.
Published in:
PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045628
By:
- Ajay, Amrendra Kumar;
- Saikumar, Janani;
- Bijol, Vanesa;
- Vaidya, Vishal S.;
- Gaetano, Carlo
Publication type:
Article
Gene Expression Analysis Reveals the Cell Cycle and Kinetochore Genes Participating in Ischemia Reperfusion Injury and Early Development in Kidney.
Published in:
PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0025679
By:
- Kim, Tae-Min;
- Ramírez, Victoria;
- Barrera-Chimal, Jonatan;
- Bobadilla, Norma A.;
- Park, Peter J.;
- Vaidya, Vishal S.
Publication type:
Article
Multi omics analysis of fibrotic kidneys in two mouse models.
Published in:
Scientific Data, 2019, v. 6, n. 1, p. N.PAG, doi. 10.1038/s41597-019-0095-5
By:
- Pavkovic, Mira;
- Pantano, Lorena;
- Gerlach, Cory V.;
- Brutus, Sergine;
- Boswell, Sarah A.;
- Everley, Robert A.;
- Shah, Jagesh V.;
- Sui, Shannan H.;
- Vaidya, Vishal S.
Publication type:
Article
Letter to the Editor: MicroRNAs 1915–3p, 2861, and 4532 Are Associated with LongTerm Renal Function Decline in Type 1 Diabetes.
Published in:
Clinical Chemistry, 2019, v. 65, n. 11, p. 1458, doi. 10.1373/clinchem.2019.307686
By:
- Monteiro, Maria Beatriz;
- Santos-Bezerra, Daniele P.;
- Pelaes, Tatiana S.;
- Vaidya, Vishal S.;
- Corrêa-Giannella, Maria Lucia
Publication type:
Article
Identification, Confirmation, and Replication of Novel Urinary MicroRNA Biomarkers in Lupus Nephritis and Diabetic Nephropathy.
Published in:
Clinical Chemistry, 2017, v. 63, n. 9, p. 1515, doi. 10.1373/clinchem.2017.274175
By:
- Cardenas-Gonzalez, Mariana;
- Srivastava, Anand;
- Pavkovic, Mira;
- Bijol, Vanesa;
- Rennke, Helmut G.;
- Stillman, Isaac E.;
- Xiaolan Zhang;
- Parikh, Samir;
- Rovin, Brad H.;
- Afkarian, Maryam;
- de Boer, Ian H.;
- Himmelfarb, Jonathan;
- Waikar, Sushrut S.;
- Vaidya, Vishal S.
Publication type:
Article
Noninvasive Micromarkers.
Published in:
Clinical Chemistry, 2014, v. 60, n. 9, p. 1158, doi. 10.1373/clinchem.2013.216044
By:
- Saikumar, Janani;
- Ramachandran, Krithika;
- Vaidya, Vishal S.
Publication type:
Article
Human miRNome Profiling Identifies MicroRNAs Differentially Present in the Urine after Kidney Injury.
Published in:
Clinical Chemistry, 2013, v. 59, n. 12, p. 1742, doi. 10.1373/clinchem.2013.210245
By:
- Ramachandran, Krithika;
- Saikumar, Janani;
- Bijol, Vanesa;
- Koyner, Jay L.;
- Jing Qian;
- Betensky, Rebecca A.;
- Waikar, Sushrut S.;
- Vaidya, Vishal S.
Publication type:
Article
Industry Perspective on Biomarker Development and Qualification.
Published in:
Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 1, p. 27, doi. 10.1002/cpt.919
By:
- Gerlach, Cory V.;
- Derzi, Mazin;
- Ramaiah, Shashi K.;
- Vaidya, Vishal S.
Publication type:
Article
Activation of PPAR-α in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.
Published in:
FASEB Journal, 2003, v. 17, n. 12, p. 1748, doi. 10.1096/fj.02-1186fje
By:
- Shankar, Kartik;
- Vaidya, Vishal S.;
- Corton, J. Christopher;
- Bucci, Thomas J.;
- Liu, Jie;
- Waalkes, Michael P.;
- Mehendale, Harihara M.
Publication type:
Article
Comparative Analysis of Novel Noninvasive Renal Biomarkers and Metabonomic Changes in a Rat Model of Gentamicin Nephrotoxicity.
Published in:
Toxicological Sciences, 2009, v. 109, n. 2, p. 336, doi. 10.1093/toxsci/kfp070
By:
- Max Sieber;
- Dana Hoffmann;
- Melanie Adler;
- Vishal S. Vaidya;
- Matthew Clement;
- Joseph V. Bonventre;
- Nadine Zidek;
- Eva Rached;
- Alexander Amberg;
- John J. Callanan;
- Wolfgang Dekant;
- Angela Mally
Publication type:
Article
Comparison of Kidney Injury Molecule-1 and Other Nephrotoxicity Biomarkers in Urine and Kidney Following Acute Exposure to Gentamicin, Mercury, and Chromium.
Published in:
Toxicological Sciences, 2008, v. 101, n. 1, p. 159, doi. 10.1093/toxsci/kfm260
By:
- Yuzhao Zhou;
- Vishal S. Vaidya;
- Ronald P. Brown;
- Jun Zhang;
- Barry A. Rosenzweig;
- Karol L. Thompson;
- Terry J. Miller;
- Joseph V. Bonventre;
- Peter L. Goering
Publication type:
Article
The Utility of a Rodent Model in Detecting Pediatric Drug-Induced Nephrotoxicity.
Published in:
Toxicological Sciences, 2007, v. 99, n. 2, p. 637, doi. 10.1093/toxsci/kfm184
By:
- Espandiari, Parvaneh;
- Zhang, Jun;
- Rosenzweig, Barry A.;
- Vaidya, Vishal S.;
- Jinchun Sun;
- Schnackenberg, Laura;
- Herman, Eugene H.;
- Knapton, Alan;
- Bonventre, Joseph V.;
- Beger, Richard D.;
- Thompson, Karol L.;
- Hanig, Joseph
Publication type:
Article
Role of Tissue Repair in Survival from S-(1,2-Dichlorovinyl)-<sub>L</sub>-Cysteine-Induced Acute Renal Tubular Necrosis in the Mouse.
Published in:
Toxicological Sciences, 2003, v. 74, n. 1, p. 215, doi. 10.1093/toxsci/kfg111
By:
- Vaidya, Vishal S.;
- Shankar, Kartik;
- Lock, Edward A.;
- Bucci, Thomas J.;
- Mehendale, Harihara M.
Publication type:
Article
Type 1 Diabetic Mice Are Protected from Acetaminophen Hepatotoxicity.
Published in:
Toxicological Sciences, 2003, v. 73, n. 2, p. 220, doi. 10.1093/toxsci/kfg059
By:
- Shankar, Kartik;
- Vaidya, Vishal S.;
- Apte, Udayan M.;
- Manautou, Jose E.;
- Ronis, Martin J. J.;
- Bucci, Thomas J.;
- Mehendale, Harihara M.
Publication type:
Article
Upregulated Promitogenic Signaling via Cytokines and Growth Factors: Potential Mechanism of Robust Liver Tissue Repair in Calorie-Restricted Rats upon Toxic Challenge.
Published in:
Toxicological Sciences, 2002, v. 69, n. 2, p. 448, doi. 10.1093/toxsci/69.2.448
By:
- Apte, Udayan M.;
- Limaye, Pallavi B.;
- Ramaiah, Shashi K.;
- Vaidya, Vishal S.;
- Bucci, Thomas J.;
- Warbritton, Alan;
- Mehendale, Harihara M.
Publication type:
Article
Urinary Biomarkers for Sensitive and Specific Detection of Acute Kidney Injury in Humans.
Published in:
CTS: Clinical & Translational Science, 2008, v. 1, n. 3, p. 200, doi. 10.1111/j.1752-8062.2008.00053.x
By:
- Vaidya, Vishal S.;
- Waikar, Sushrut S.;
- Ferguson, Michael A.;
- Collings, Fitz B.;
- Sunderland, Kelsey;
- Gioules, Costas;
- Bradwin, Gary;
- Matsouaka, Roland;
- Betensky, Rebecca A.;
- Curhan, Gary C.;
- Bonventre, Joseph V.
Publication type:
Article
Differences in Immunolocalization of Kim-1, RPA-1, and RPA-2 in Kidneys of Gentamicin-, Cisplatin-, and Valproic Acid-Treated Rats: Potential Role of iNOS and Nitrotyrosine.
Published in:
Toxicologic Pathology, 2009, v. 37, n. 5, p. 629, doi. 10.1177/0192623309339605
By:
- Jun Zhang;
- Goering, Peter L.;
- Espandiari, Parvaneh;
- Shaw, Martin;
- Bonventre, Joseph V.;
- Vaidya, Vishal S.;
- Brown, Ronald P.;
- Keenan, Joe;
- Kilty, Cormac G.;
- Sadrieh, Nakissa;
- Hanig, Joseph P.
Publication type:
Article
Immunolocalization of Kim-1, RPA-1, and RPA-2 in Kidney of Gentamicin-, Mercury-, or Chromium-Treated Rats: Relationship to Renal Distributions of iNOS and Nitrotyrosine.
Published in:
Toxicologic Pathology, 2008, v. 36, n. 3, p. 397, doi. 10.1177/0192623308315832
By:
- JUN ZHANG;
- BROWN, RONALD P.;
- SHAW, MARTIN;
- VAIDYA, VISHAL S.;
- ZHOU, YUZHAO;
- ESPANDIARI, PARVANEH;
- SADRIEH, NAKISSA;
- STRATMEYER, MELVIN;
- KEENAN, JOE;
- KILTY, CORMAC G.;
- BONVENTRE, JOSEPH V.;
- GOERING, PETER L.
Publication type:
Article
Molecular Mechanisms of Renal Tissue Repair in Survival from Acute Renal Tubule Necrosis: Role of ERK1/2 Pathway.
Published in:
Toxicologic Pathology, 2003, v. 31, n. 6, p. 604, doi. 10.1080/01926230390241945
By:
- Vaidya, Vishal S.;
- Shankar, Kartik;
- Lock, Edward A.;
- Dixon, Darlene;
- Mehendale, Harihara M.
Publication type:
Article
Qualified kidney injury biomarkers demonstrate value during early clinical drug development.
Published in:
Toxicological Sciences, 2024, v. 201, n. 2, p. 206, doi. 10.1093/toxsci/kfae088
By:
- Ravindra, Kodihalli C;
- Fader, Kelly A;
- Potter, David;
- Radi, Zaher A;
- Friedman, Gary S;
- Brenneman, Karrie A;
- Amin, Neeta B;
- Weiss, Roberta;
- Danto, Spencer I;
- Page, Karen;
- Ramaiah, Shashi K;
- Vaidya, Vishal S
Publication type:
Article
Evaluating the Sensitivity and Specificity of Promising Circulating Biomarkers to Diagnose Liver Injury in Humans.
Published in:
Toxicological Sciences, 2021, v. 181, n. 1, p. 23, doi. 10.1093/toxsci/kfab003
By:
- Llewellyn, Heather P;
- Vaidya, Vishal S;
- Wang, Zhenyu;
- Peng, Qinghai;
- Hyde, Craig;
- Potter, David;
- Wang, Jianying;
- Zong, Qing;
- Arat, Seda;
- Martin, Matt;
- Masek-Hammerman, Katherine;
- Warner, Roscoe;
- Johnson, Kent;
- Kullak-Ublick, Gerd A;
- Aithal, Guruprasad P;
- Dear, James W;
- Ramaiah, Shashi K
Publication type:
Article
Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers.
Published in:
Toxicological Sciences, 2020, v. 176, n. 1, p. 124, doi. 10.1093/toxsci/kfaa049
By:
- Khodabukus, Alastair;
- Kaza, Amulya;
- Wang, Jason;
- Prabhu, Neel;
- Goldstein, Richard;
- Vaidya, Vishal S;
- Bursac, Nenad
Publication type:
Article
A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro.
Published in:
Toxicological Sciences, 2019, v. 169, n. 1, p. 54, doi. 10.1093/toxsci/kfz021
By:
- Ramm, Susanne;
- Todorov, Petar;
- Chandrasekaran, Vidya;
- Dohlman, Anders;
- Monteiro, Maria B;
- Pavkovic, Mira;
- Muhlich, Jeremy;
- Shankaran, Harish;
- Chen, William W;
- Mettetal, Jerome T;
- Vaidya, Vishal S
Publication type:
Article
Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423.
Published in:
Toxicological Sciences, 2016, v. 152, n. 1, p. 205, doi. 10.1093/toxsci/kfw077
By:
- Pavkovic, Mira;
- Robinson-Cohen, Cassianne;
- Chua, Alicia S.;
- Nicoara, Oana;
- Cárdenas-González, Mariana;
- Bijol, Vanesa;
- Ramachandran, Krithika;
- Hampson, Lucy;
- Pirmohamed, Munir;
- Antoine, Daniel J.;
- Frendl, Gyorgy;
- Himmelfarb, Jonathan;
- Waikar, Sushrut S.;
- Vaidya, Vishal S.
Publication type:
Article
MicroRNA-155 Deficient Mice Experience Heightened Kidney Toxicity When Dosed with Cisplatin.
Published in:
Toxicological Sciences, 2014, v. 141, n. 2, p. 484, doi. 10.1093/toxsci/kfu143
By:
- Pellegrini, Kathryn L.;
- Han, Tao;
- Bijol, Vanesa;
- Saikumar, Janani;
- Craciun, Florin L.;
- Chen, William W.;
- Fuscoe, James C.;
- Vaidya, Vishal S.
Publication type:
Article
Expression, Circulation, and Excretion Profile of MicroRNA-21, -155, and -18a Following Acute Kidney Injury.
Published in:
Toxicological Sciences, 2012, v. 129, n. 2, p. 256, doi. 10.1093/toxsci/kfs210
By:
- Saikumar, Janani;
- Hoffmann, Dana;
- Kim, Tae-Min;
- Gonzalez, Victoria Ramirez;
- Zhang, Qin;
- Goering, Peter L.;
- Brown, Ronald P.;
- Bijol, Vanesa;
- Park, Peter J.;
- Waikar, Sushrut S.;
- Vaidya, Vishal S.
Publication type:
Article
TIM2 Gene Deletion Results in Susceptibility to Cisplatin-Induced Kidney Toxicity.
Published in:
Toxicological Sciences, 2010, v. 118, n. 1, p. 298, doi. 10.1093/toxsci/kfq240
By:
- Krishnamoorthy, Aparna;
- Clement, Matthew E.;
- O'leary, Eileen;
- Bonventre, Joseph V.;
- Vaidya, Vishal S.
Publication type:
Article
Performance of Novel Kidney Biomarkers in Preclinical Toxicity Studies.
Published in:
Toxicological Sciences, 2010, v. 116, n. 1, p. 8, doi. 10.1093/toxsci/kfq029
By:
- Hoffmann, Dana;
- Adler, Melanie;
- Vaidya, Vishal S.;
- Rached, Eva;
- Mulrane, Laoighse;
- Gallagher, William M.;
- Callanan, John J.;
- Gautier, Jean C.;
- Matheis, Katja;
- Staedtler, Frank;
- Dieterle, Frank;
- Brandenburg, Arnd;
- Sposny, Alexandra;
- Hewitt, Philip;
- Ellinger-Ziegelbauer, Heidrun;
- Bonventre, Joseph V.;
- Dekant, Wolfgang;
- Mally, Angela
Publication type:
Article

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