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- Title
NetDS: a Cytoscape plugin to analyze the robustness of dynamics and feedforward/feedback loop structures of biological networks.
- Authors
Le, Duc-Hau; Kwon, Yung-Keun
- Abstract
Summary: NetDS is a novel Cytoscape plugin that conveniently simulates dynamics related to robustness, and examines structural properties with respect to feedforward/feedback loops. It can evaluate how robustly a network sustains a stable state against mutations by employing a Boolean network model. In addition, the plugin can examine all feedforward/feedback loops appearing in a network and determine whether or not a pair of loops is coupled. Random networks can also be generated to evaluate whether or not an interesting finding in real biological networks is significantly random.Availability: NetDS is freely available for non-commercial purposes at http://netds.sourceforge.net/.Contact: kwonyk@ulsan.ac.krSupplementary information: Supplementary data are available at Bioinformatics online.
- Subjects
MOLECULAR dynamics; MOLECULAR structure; ROBUST control; MATHEMATICAL models; GENETIC mutation; SIMULATION methods &; models; COMPUTER networks
- Publication
Bioinformatics, 2011, Vol 27, Issue 19, p2767
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btr466