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- Title
Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis.
- Authors
Xiong, Anji; Liu, Qingting; Zhong, Jiaxun; Cao, Yuzi; Xiang, Qilang; Hu, Ziyi; Zhou, Shifeng; Song, Zhuoyao; Chen, Huini; Zhang, Yan; Cui, Hongxu; Shuai, Shiquan
- Abstract
Background: Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods: We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results: The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions: This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc.
- Publication
Advances in Rheumatology, 2022, Vol 62, Issue 1, p1
- ISSN
2523-3106
- Publication type
Article
- DOI
10.1186/s42358-022-00239-2