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- Title
Nickel‐Catalyzed 1,1‐Difluoroethylation of (Hetero)aryl Halides with 1,1‐Difluoroethyl Chloride (CH<sub>3</sub>CF<sub>2</sub>Cl).
- Authors
Liu, Jianchang; Zhang, Jida; Li, Xiangye; Wu, Chaolin; Liu, Hefu; Liu, Hui; Sun, Fenggang; Li, Yueyun; Liu, Yuying; Li, Xinjin
- Abstract
1,1‐Difluoroethylated aromatic compounds are of increasing importance in agrochemicals and pharmaceuticals. The direct introduction of difluoroethyl (CF2CH3) group(s) onto aromatic rings using CH3CF2Cl, an inexpensive and available raw material, still remains a great challenge because of the relatively inert C−Cl bond of CH3CF2Cl. Herein, we disclose a nickel‐catalyzed 1,1‐difluoroethylation of (hetero)aryl halides with CH3CF2Cl. The reaction exhibits good functional‐group tolerance and is regarded as a practical method for synthesis of (1,1‐difluoroethyl)arenes.
- Subjects
ARYL halides; ARYL chlorides; CHLORIDES; AROMATIC compounds; RAW materials
- Publication
Asian Journal of Organic Chemistry, 2020, Vol 9, Issue 3, p391
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202000004