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- Title
Comparison of [<sup>18</sup>F]FIMP, [<sup>11</sup>C]MET, and [<sup>18</sup>F]FDG PET for early-phase assessment of radiotherapy response.
- Authors
Nozaki, Satoshi; Nakatani, Yuka; Mawatari, Aya; Shibata, Nina; Hume, William E.; Hayashinaka, Emi; Wada, Yasuhiro; Doi, Hisashi; Watanabe, Yasuyoshi
- Abstract
Several limitations of [18F]FDG have been reported, such as nonspecific uptake of inflammation foci. Moreover, [11C]MET has been found to accumulate in normal and inflammatory tissues as well as tumors. To increase specificity to tumor tissues, PET probes with tumor-specific molecular targets have been actively developed. [18F]FIMP was found to be highly accumulated in LAT1-positive tumors but not in inflamed tissue. The aim of this study was to explore whether [18F]FIMP can be used for the early-phase evaluation of radiotherapy accompanied by inflammation, and compare its effectiveness with those of [11C]MET and [18F]FDG. Tumor uptake of [18F]FIMP decreased at day 1 after irradiation, and remained low until day 14. Comparatively, that of [18F]FDG initially decreased at day 3 but was transiently elevated at day 7 and then decreased again at day 10. Decreased tumor uptake of [11C]MET was observed at day 10. In line with the uptake of [18F]FIMP, the ratio of Ki-67 immuno-positive cells in tumor tissues significantly decreased at day 1, 7, and 10 as compared with that in the control. These findings suggest that [18F]FIMP may be a PET probe involved in the early detection and prediction of radiotherapy efficacy, although further clarification is needed.
- Subjects
MOLECULAR probes; DRUG target; RADIOTHERAPY; KI-67 antigen; POSITRON emission tomography
- Publication
Scientific Reports, 2023, Vol 13, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-023-29166-y