We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Symptomatic Neonatal Seizures Followed by Febrile Status Epilepticus: The two-Hit Hypothesis for the Subsequent Development of Epilepsy.
- Authors
Spagnoli, Carlotta; Cilio, Maria Roberta; Pavlidis, Elena; Pisani, Francesco
- Abstract
Neonatal seizures have been associated with the later development of postneonatal epilepsy, mainly beginning within the first year of life. Mechanisms of epileptogenesis in the immature brain still need to be fully elucidated but a two-hit hypothesis, showing that an early insult heightens later susceptibility to seizure-induced brain damage, has been demonstrated in animal models. We describe 2 cases of preterm babies sustaining recurrent neonatal seizures in the context of a severe perinatal brain damage who presented with symptomatic epilepsy only after the occurrence of an episode of febrile status epilepticus. In the context of preexisting perinatal brain damage, febrile status epilepticus acted as a second hit for developing epilepsy, confirming animal evidence.
- Subjects
STATUS epilepticus; EPILEPSY; PHILOSOPHY of science; BRAIN diseases; PYRAMIDAL neurons
- Publication
Journal of Child Neurology, 2015, Vol 30, Issue 5, p615
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073814533004