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- Title
The kinetics of circulating cytokines including IL-6, TNF-α, IL-8 and IL-10 following allogeneic hematopoietic stem cell transplantation.
- Authors
Min, C-K; Lee, W Y; Min, D-J; Lee, D-G; Kim, Y-J; Park, Y H; Kim, H J; Lee, S; Kim, D W; Lee, J W; Min, W S; Kim, C C
- Abstract
Pro-inflammatory (IL-6, TNFα and IL-8) and anti-inflammatory (IL-10) cytokines were determined in weekly samples from 52 patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). IL-6 increased immediately after transplant peaking at week +3, but IL-8 concentrations were elevated only during week +1. After a slight decrease in week +1, TNF-α significantly increased from week +2 and peaked at week +3, whereas, IL-10 values started to rise in week +2 and peaked during week +4. IL-6 and TNF-α were positively correlated from week +2 to week +4, and IL-6 levels at week +1 were related with fever and severe stomatitis. Serum levels of IL-6 at week +1 and IL-10 at week +4 were significantly higher in patients with early transplant-related complications, such as fever, severe stomatitis or acute GVHD overall grade II than in those without the complications. We conclude that a high serum IL-6 level at week +1 may be an early predictor of transplant-related complications and that it seems to trigger pro- and anti-inflammatory cytokine release. Kinetic patterns of IL-6 and IL-10 were more exaggerated in those with complications after HSCT. Bone Marrow Transplantation (2001) 28, 935–940.
- Subjects
HOMOGRAFTS; CYTOKINES; COMPLICATIONS from organ transplantation
- Publication
Bone Marrow Transplantation, 2001, Vol 28, Issue 10, p935
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1703258