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- Title
Successful treatment of resistant thrombotic thrombocytopenic purpura/hemolytic uremic syndrome with autologous peripheral blood stem and progenitor (CD34<sup>+</sup>) cell transplantation.
- Authors
Musso, M; Porretto, F; Crescimanno, A; Bondì, F; Polizzi, V; Scalone, R; Iannitto, E; Mariani, G
- Abstract
The first-line treatment of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS syndrome) induces a response and survival rate of approximately 85%, even if a considerable number of patients relapse; nevertheless, a number of these patients are resistant to conventional management. Immunoablation followed by stem cell transplantation has been shown to be capable of inducing remissions in a large spectrum of experimental autoimmune disorders. We report here the case of a 20-year-old male patient with the TTP-HUS syndrome who was resistant to conventional treatment and was transplanted with autologous immunoselected CD34+ PBPC after conditioning with cyclosphosphamide, anti-T lymphocyte globulin and prednisone. Seven months after transplant the patient is alive and well, without any further treatment being given.
- Subjects
THROMBOTIC thrombocytopenic purpura; HEMOLYTIC-uremic syndrome; AUTOTRANSPLANTATION; STEM cell transplantation
- Publication
Bone Marrow Transplantation, 1999, Vol 24, Issue 2, p207
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1701859