We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Predictive factors of flares in systemic lupus erythematosus patients: data from a multiethnic Latin American cohort.
- Authors
Ugarte-Gil, M. F.; Wojdyla, D.; Pastor-Asurza, C. A.; Gamboa-Cárdenas, R. V.; Acevedo-Vásquez, E. M.; Catoggio, L. J.; García, M. A.; Bonfá, E.; Sato, E. I.; Massardo, L.; Pascual-Ramos, V.; Barile, L. A.; Reyes-Llerena, G.; Iglesias-Gamarra, A.; Molina-Restrepo, J. F.; Chacón-Díaz, R.; Alarcón, G. S.; Pons-Estel, B. A.
- Abstract
Purpose: The purpose of this paper is to determine the factors predictive of flares in systemic lupus erythematosus (SLE) patients. Methods: A case-control study nested within the Grupo Latino Americano De Estudio de Lupus (GLADEL) cohort was conducted. Flare was defined as an increase ≥4 points in the SLEDAI. Cases were defined as patients with at least one flare. Controls were selected by matching cases by length of follow-up. Demographic and clinical manifestations were systematically recorded by a common protocol. Glucocorticoid use was recorded as average daily dose of prednisone and antimalarial use as percentage of time on antimalarial and categorized as never (0%), rarely (>0-25%), occasionally (>25%-50%), commonly (>50%-75%) and frequently (>75%). Immunosuppressive drugs were recorded as used or not used. Results: A total of 465 cases and controls were included. Mean age at diagnosis among cases and controls was 27.5 vs 29.9 years, p=0.003; gender and ethnic distributions were comparable among both groups and so was the baseline SLEDAI. Independent factors protective of flares identified by multivariable analysis were older age at diagnosis (OR=0.929 per every five years, 95% CI 0.869-0.975; p=0.004) and antimalarial use (frequently vs never, OR=0.722, 95% CI 0.522-0.998; p=0.049) whereas azathioprine use (OR=1.820, 95% CI 1.309-2.531; p<0.001) and SLEDAI post-baseline were predictive of them (OR=1.034, 95% CI 1.005-1.064; p=0.022). Conclusions: In this large, longitudinal Latin American cohort, older age at diagnosis and more frequent antimalarial use were protective whereas azathioprine use and higher disease activity were predictive of flares.
- Subjects
SYSTEMIC lupus erythematosus diagnosis; SYSTEMIC lupus erythematosus; SYSTEMIC lupus erythematosus treatment; ANTIMALARIALS; GLUCOCORTICOIDS; DISEASE risk factors
- Publication
Lupus, 2018, Vol 27, Issue 4, p536
- ISSN
0961-2033
- Publication type
Article
- DOI
10.1177/0961203317728810