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- Title
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age.
- Authors
Harris, Sarah E.; Cox, Simon R.; Bell, Steven; Marioni, Riccardo E.; Prins, Bram P.; Pattie, Alison; Corley, Janie; Muñoz Maniega, Susana; Valdés Hernández, Maria; Morris, Zoe; John, Sally; Bronson, Paola G.; Tucker-Drob, Elliot M.; Starr, John M.; Bastin, Mark E.; Wardlaw, Joanna M.; Butterworth, Adam S.; Deary, Ian J.
- Abstract
Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N = 798), Lothian Birth Cohort 1921 (LBC1921, N = 165), and the INTERVAL BioResource (N = 4451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between −0.11 and −0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases. Late-life cognitive dysfunction is common, but the biological substrates are largely unknown. Here, the authors examined a panel of 90 neurology-related protein biomarkers and show that plasma levels of 22 of these proteins are associated with general fluid cognitive ability in later life.
- Subjects
COGNITIVE ability; BIOLOGICAL tags; PROTEINS; PROTEOMICS
- Publication
Nature Communications, 2020, Vol 11, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-019-14161-7