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- Title
Preparation and Properties of Degradable Hydrogels Based on Diallyl Terminated Cyclic Acetal and PEG Monomer.
- Authors
KEMIN WANG; NAN ZHANG; JIAN LU; RUIXUE YIN; JUN NIE; QIANG YU
- Abstract
Synthetic, hydrolytically degradable biomaterials have been widely developed for biomedical use. However, there are only a few examples whose polymer backbone does not form acidic products upon degradation. In order to address this concern, we proposed to develop a novel hydrogel based on cyclic acetal units that produced diols and propanals upon hydrolytic degradation. The fabrication of hydrogels was achieved by thiol-ene photopolymerization of cyclic acetal and PEG diallyl monomers (EHDA and PEGDAL) in presence of multifunctional thiols. This degradable hydrogel based upon hydrophobic degradable segments of EHDA and hydrophilic segments of PEGDAL, produced diols and carbonyl end groups upon hydrolytic degradation and could be entirely devoid of acidic by-products. The chemical structure of the resulting hydrogel and thiol-ene photopolymerization kinetics were investigated by FT-IR. TGA analysis showed that the hydrogels exhibited a typical weight loss (97%) from around 320 °C to 500 °C. Degradation of this hydrogel was investigated in PBS medium so as to simulate physiological conditions. The remaining mass of the materials after 25 days incubation was 93%. In vitro cytotoxicity showed that the hydrogels had non-toxicity to cell L-929 and had good biocompatibility. The results indicate that this hydrogel has the potential to be used for longterm controlled drug delivery and implants.
- Subjects
HYDROGELS; ACETAL resins; POLYETHYLENE glycol; BIODEGRADABLE products; BIOMEDICAL materials; MONOMERS; PHOTOPOLYMERIZATION kinetics
- Publication
Journal of Polymer Materials, 2014, Vol 31, Issue 1, p89
- ISSN
0973-8622
- Publication type
Article