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- Title
Sodium-Magnesium Exchange in Erythrocyte Membranes from Patients with Affective Disorders.
- Authors
Widmer, Jean; Féray, Jean-Claude; Bovier, Philippe; Hilleret, Henriette; Raffin, Yvette; Chollet, Didier; Gaillard, Jean-Michel; Garay, Ricardo
- Abstract
The Vmax of erythrocyte sodium-magnesium exchange was measured for the first time in 63 patients suffering from affective disorders and compared to that in 33 healthy subjects. Depressed patients had a significantly higher Vmax (215 ± 13 vs. 151 ± 14 μmol/l·· cells/h;p< 0.005; mean ± SEM). This tendency was conserved after division of the 63 patients into three clinical subgroups according to the DSM-III-R criteria. Thirty-four patients from this panel were divided into three subgroups according to the chemical class of the antidepressant drug used and were followed up during a 3-month period of drug treatment. Mood improvement over the 3-month period was associated with a slow increase in Vmax of Na/Mg exchange (Δ increase &thkap;25 μmol/l·cells/h), except in the subgroup of patients treated with non-tricyclic antidepressants (n = 8). These results are consistent with the previously reported link between high erythrocyte magnesium content and affective disorders. Indeed, enhanced Na/ Mg exchange Vmax, which probably results from an increased number of transport units per cell, contributes to the normalization of red blood cell magnesium content correlated with mood improvement. Copyright © 1995 S. Karger AG, Basel
- Publication
Neuropsychobiology, 1995, Vol 32, Issue 1, p13
- ISSN
0302-282X
- Publication type
Article
- DOI
10.1159/000119206