We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Pro-inflammatory profiles in cardiovascular disease patients with peri-implantitis.
- Authors
Wang, I‐Ching; Sugai, Jim V.; Majzoub, Jad; Johnston, Jeffery; Giannobile, William V.; Wang, Hom‐Lay; Wang, I-Ching; Wang, Hom-Lay
- Abstract
<bold>Background: </bold>To investigate the pro-inflammatory cytokine profiles in patients with or without cardiovascular disease (CVD) and with or without peri-implantitis.<bold>Methods: </bold>Serum, peri-implant crevicular fluid (PICF), and gingival crevicular fluid (GCF) were collected from patients with (n = 82) or without CVD (n = 46) at the most severe peri-implantitis site including sites with periodontitis. A panel of proinflammatory molecules including high-sensitivity C-reactive protein (hsCRP), fibrinogen, interleukin-1 beta (IL-1β), IL-6, plasma tumor necrosis factor-alpha (TNF-α), matrix metallo-proteinase-8 (MMP-8), osteoprotegerin (OPG), vascular endothelial growth factor (VEGF), IL-17, IL-8, tissue inhibitor of metalloproteinase-2 (TIMP-2), myeloperoxidase (MPO), and prostaglandin E2 (PGE2 ) were analyzed using human custom Quantibody arrays. Krunskal-Wallis test was used to compare groups. The diagnostic ability of each biomarker was assessed using chi-square test and ROC analysis.<bold>Results: </bold>Serum IL-1β, TNF-α and fibrinogen were significantly higher in CVD patients than those without. Serum fibrinogen displayed a trend of higher concentration in patients with radiographic bone loss (RBL) ≥2 mm (P = 0.08). PICF TNF-α exhibited a significantly higher detection level in the CVD patients that is coincided with the local peri-implant inflammation. In addition, PICF MMP-8 was significantly higher in the RBL ≥2 mm sites than the healthy implants; whereas IL-1β, IL-8, MMP-8, and TIMP-2 proved to be the significant predictors for peri-implant disease. GCF TNF-α collected from patients with periodontitis was significantly associated with CVD cases.<bold>Conclusion: </bold>The augmented expression of local and systemic pro-inflammatory cytokines found in the current study supports the weak association between the chronic peri-implantitis with increasing severity and CVD.
- Subjects
CARDIOVASCULAR diseases; PERI-implantitis; CYTOKINES; INFLAMMATION; DENTAL implants; CARDIOVASCULAR diseases risk factors; PROTEIN metabolism; INTERLEUKINS; KRUSKAL-Wallis Test; PERIODONTITIS; CROSS-sectional method; PROTEOLYTIC enzymes; CASE-control method; PEARSON correlation (Statistics); FIBRINOGEN; TUMOR necrosis factors; EXUDATES &; transudates; DESCRIPTIVE statistics; ANALYSIS of covariance; RESEARCH funding; VASCULAR endothelial growth factors; ODDS ratio; RECEIVER operating characteristic curves; DATA analysis software; DISEASE complications
- Publication
Journal of Periodontology, 2022, Vol 93, Issue 6, p824
- ISSN
0022-3492
- Publication type
journal article
- DOI
10.1002/JPER.21-0419