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- Title
Association between peri-implantitis and cardiovascular diseases: A case-control study.
- Authors
Wang, I‐Ching; Ou, Alice; Johnston, Jeffery; Giannobile, William V.; Yang, Bo; Fenno, J. Christopher; Wang, Hom‐Lay; Wang, I-Ching; Wang, Hom-Lay
- Abstract
<bold>Background: </bold>This study assesses the association between peri-implantitis and cardiovascular diseases (CVD).<bold>Methods: </bold>One hundred and twenty-eight patients with dental implants were recruited to evaluate the prevalence of peri-implantitis in patients with or without CVD (CVD group, n = 82, control group, n = 46, respectively). Diagnosis of peri-implantitis followed the 2017 World Workshop guidelines and the severity was defined as mild, moderate, and severe form when the radiographic bone loss (RBL) was <2, 2 to 4, and >4 mm. Multivariable logistic regression was performed to test the association between two diseases.<bold>Results: </bold>A trend of higher prevalence of peri-implantitis defined by detectable RBL beyond the physiologic bone remodeling was found in the CVD group (64.6%) when compared with the controls (56.5%). A significant higher prevalence (48.8%) of moderate to severe peri-implantitis was identified in CVD compared with controls(30.4%) with a significant crude association between moderate to severe peri-implantitis and CVD (odds ratio = 2.18, 95% CI, 1.02 to 4.67; P = 0.04). The CVD group had a trend of higher prevalence of deep pockets (≥7 mm) and higher numbers of sites with bleeding on probing (>66%) when compared with controls (P > 0.05). However, after controlling for multiple confounders including age, hypertension, smoking, family history of heart attack, and periodontitis, the significant association was not found.<bold>Conclusions: </bold>CVD group had significantly higher prevalence of moderate to severe peri-implantitis (RBL ≥2 mm). The association between the two diseases did not exist after controlling multiple confounders for CVD. Future studies with a larger sample size controlling for the patient- and implant-related confounders are needed to better understand the link between peri-implantitis and CVD.
- Subjects
CARDIOVASCULAR diseases; DENTAL implants; HEART disease risk factors; PERI-implantitis; ORAL diseases; PERIODONTITIS; BONE resorption; CASE-control method; DISEASE complications
- Publication
Journal of Periodontology, 2022, Vol 93, Issue 5, p633
- ISSN
0022-3492
- Publication type
journal article
- DOI
10.1002/JPER.21-0418