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- Title
Fundamental Dynamical Modes Underlying Human Brain Synchronization.
- Authors
Alvarado-Rojas, Catalina; Le Van Quyen, Michel
- Abstract
Little is known about the long-term dynamics of widely interacting cortical and subcortical networks during the wake-sleep cycle. Using large-scale intracranial recordings of epileptic patients during seizure-free periods, we investigated local- and long-range synchronization between multiple brain regions over several days. For such high-dimensional data, summary information is required for understanding and modelling the underlying dynamics. Here, we suggest that a compact yet useful representation is given by a state space based on the first principal components. Using this representation, we report, with a remarkable similarity across the patients with different locations of electrode placement, that the seemingly complex patterns of brain synchrony during the wake-sleep cycle can be represented by a small number of characteristic dynamic modes. In this space, transitions between behavioral states occur through specific trajectories from one mode to another. These findings suggest that, at a coarse level of temporal resolution, the different brain states are correlated with several dominant synchrony patterns which are successively activated across wake-sleep states.
- Subjects
PEOPLE with epilepsy; BRAIN function localization; MOLECULAR dynamics; PATTERN recognition systems; TRAJECTORIES (Mechanics); PRINCIPAL components analysis
- Publication
Computational & Mathematical Methods in Medicine, 2012, p1
- ISSN
1748-670X
- Publication type
Article
- DOI
10.1155/2012/912729