We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Clearance of amyloid-β by circulating lipoprotein receptors.
- Authors
Sagare, Abhay; Deane, Rashid; Bell, Robert D.; Johnson, Bradley; Hamm, Katie; Pendu, Ronan; Marky, Andrew; Lenting, Peter J.; Zhenhua Wu; Zarcone, Troy; Goate, Alison; Mayo, Kevin; Perlmutter, David; Coma, Mireia; Zhihui Zhong; Zlokovic, Berislav V.
- Abstract
Low-density lipoprotein receptor–related protein-1 (LRP) on brain capillaries clears amyloid β-peptide (Aβ) from brain. Here, we show that soluble circulating LRP (sLRP) provides key endogenous peripheral 'sink' activity for Aβ in humans. Recombinant LRP cluster IV (LRP-IV) bound Aβ in plasma in mice and Alzheimer's disease–affected humans with compromised sLRP-mediated Aβ binding, and reduced Aβ-related pathology and dysfunction in a mouse model of Alzheimer disease, suggesting that LRP-IV can effectively replace native sLRP and clear Aβ.
- Subjects
LIPOPROTEINS; LIPIDS; AMYLOID; ALZHEIMER'S disease; PRESENILE dementia; LABORATORY mice
- Publication
Nature Medicine, 2007, Vol 13, Issue 9, p1029
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm1635