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- Title
Amyloid at the blood vessel wall.
- Authors
Hardy, John; Cullen, Karen
- Abstract
The article discusses the relationship between the vascular and parenchymal lesions in beta-amyloidopathy, which suggests that Alzheimer disease may have been caused by hardening of the arteries. This is in reference to a study that discovered amyloid precursor protein gene duplications in French families with beta-amyloidopathy. The phenotype of these individuals is variable with some having a purely demented phenotype, others having a hemorrhagic phenotype, and the remaining having a mixture of both. Amyloid-beta protein may have complementary damage-response functions such as an emergency sealant of the vasculature during hemorrhage or as a neuronal depressant to reduce the brain’s oxygen requirement during an ischemic event.
- Subjects
ALZHEIMER'S disease; AMYLOID beta-protein; BRAIN blood-vessels; NEUROLOGY; MEDICAL genetics
- Publication
Nature Medicine, 2006, Vol 12, Issue 7, p756
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm0706-756