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- Title
Effect of Periodontal Treatment on HbA1c among Patients with Prediabetes.
- Authors
Kocher, T.; Holtfreter, B.; Petersmann, A.; Eickholz, P.; Hoffmann, T.; Kaner, D.; Kim, T. S.; Meyle, J.; Schlagenhauf, U.; Doering, S.; Gravemeier, M.; Prior, K.; Rathmann, W.; Harks, I.; Ehmke, B.; Koch, R.
- Abstract
Evidence is limited regarding whether periodontal treatment improves hemoglobin A1c (HbA1c) among people with prediabetes and periodontal disease, and it is unknown whether improvement of metabolic status persists >3 mo. In an exploratory post hoc analysis of the multicenter randomized controlled trial "Antibiotika und Parodontitis" (Antibiotics and Periodontitis)-a prospective, stratified, double-blind study-we assessed whether nonsurgical periodontal treatment with or without an adjunctive systemic antibiotic treatment affects HbA1c and high-sensitivity C-reactive protein (hsCRP) levels among periodontitis patients with normal HbA1c (≤5.7%, n = 218), prediabetes (5.7% < HbA1c < 6.5%, n = 101), or unknown diabetes (HbA1c ≥ 6.5%, n = 8) over a period of 27.5 mo. Nonsurgical periodontal treatment reduced mean pocket probing depth by >1 mm in both groups. In the normal HbA1c group, HbA1c values remained unchanged at 5.0% (95% CI, 4.9% to 6.1%) during the observation period. Among periodontitis patients with prediabetes, HbA1c decreased from 5.9% (95% CI, 5.9% to 6.0%) to 5.4% (95% CI, 5.3% to 5.5%) at 15.5 mo and increased to 5.6% (95% CI, 5.4% to 5.7%) after 27.5 mo. At 27.5 mo, 46% of periodontitis patients with prediabetes had normal HbA1c levels, whereas 47.9% remained unchanged and 6.3% progressed to diabetes. Median hsCRP values were reduced in the normal HbA1c and prediabetes groups from 1.2 and 1.4 mg/L to 0.7 and 0.7 mg/L, respectively. Nonsurgical periodontal treatment may improve blood glucose values among periodontitis patients with prediabetes (ClinicalTrials.gov NCT00707369).
- Subjects
PREDIABETIC state; PERIODONTITIS; PERIODONTAL disease treatment; HEMOGLOBINS; C-reactive protein; ANTIBIOTICS; PERIODONTITIS treatment; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; TYPE 2 diabetes; RESEARCH; EVALUATION research; TREATMENT effectiveness; BLIND experiment; DISEASE complications
- Publication
Journal of Dental Research, 2019, Vol 98, Issue 2, p171
- ISSN
0022-0345
- Publication type
journal article
- DOI
10.1177/0022034518804185