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- Title
Impact of body temperature on cardiovascular responses during hydrogen sulfide (H<sub>2</sub>S) breathing.
- Authors
Volpato, Gian Paolo; Searles, Robert; Scherrer-Crosbie, Marielle; Bloch, Kenneth D.; Ichinose, Fumito; Zapol, Warren M.
- Abstract
In C57BL6 mice with telemeters, breathing H2S (80 ppm) at 27°C ambient temperature (Ta) for 6 h, markedly reduced heart rate (HR) (520±20 to 258±34bpm, mean±SE, P<0.05), core body temperature (Tb) (from 37.3±0.4 to 29.2±0.5, P<0.05), activity and respiratory rate (RR), but not mean arterial pressure (MAP). Values returned to control after breathing air for 3 h. Echocardiography demonstrated HES reduced HR (from 690a:19 to 233±23 bpm, P<0.05) and cardiac output (CO, from 19±l to 7±1 ml/min P<0.05) but preserved stroke volume (SV). To determine if the inhibitory effects of H2S on metabolism were due to hypothermia, we studied the response to breathing H2S in a warm chamber. Inhaling H2S for 6h with Tb of 35°C decreased HR, activity, RR and CO (from 19±1 to 10±l ml/min P<0.05), preserved SV, and increased MAP compared to 27°C H2S breathing (P<0.05). Exhaled CO2 production was measured in mice breathing H2S for 30 min at either 27 or 35°C. Breathing H2S for 5 min decreased CO2 production in both groups (from 50±6 to 28±2 and from 59±1 to 44±1 µM/min respectively, both P<0.05 vs. baseline). These results suggest breathing 80ppm H2S reversibly decreases murine metabolic rate. Supported by NIH grants HL 42397 and 71987.
- Subjects
BODY temperature; HYDROGEN sulfide; RESPIRATION; METABOLISM; CARDIOVASCULAR system; LABORATORY mice
- Publication
FASEB Journal, 2007, Vol 21, Issue 6, pA1400
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fasebj.21.6.a1400