We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Validation and Quantification of Osteoclasts as a Predictor of Polyethylene Particle Induced Osteolysis.
- Authors
Neuerburg, Carl; Kauther, Max Daniel; Bachmann, Hagen Sjard; Wedemeyer, Christian
- Abstract
Aseptic loosening is a major cause of implant failure in endoprosthetic surgery. However, it remains unclear if there is a correlation between the osteoclast number and extent of particle induced osteolysis (PIO) which might be affected by osteoclast activity. Therefore the aim of the present study was the evaluation and validation of the osteoclast number as a predictor of PIO. Data on an established murine calvarial model of UHMWPE - particle induced osteolysis in C57Bl6 mice were analysed. Osteoclast number and osteolysis was detected by counting TRAP positive cells and via histomorphometry. Pearson's correlation and ROC analysis were calculated to obtain sensitivity and specificity of the osteoclast count. There was significantly more osteolysis in particle treated animals accompanied by a significant increase of the osteoclast number. At a mean osteoclast number of 12.4, sensitivity was 83.9% and specificity 82.8%. In conclusion there is strong evidence that the osteoclast number is a reliable predictor of UHMWPE - PIO in the murine calvarial model. Further investigations will have to show if available in vivo markers of osteoclasts are useful for the early detection of PIO and subsequent therapy to improve the performance of prosthetic implants in future.
- Subjects
OSTEOCLASTS; POLYETHYLENE; BONE resorption; PROSTHETICS; ASEPTIC &; antiseptic surgery
- Publication
Trends in Biomaterials & Artificial Organs, 2012, Vol 26, Issue 4, p161
- ISSN
0971-1198
- Publication type
Article