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- Title
Relación entre polimorfismo BsmI y perfil de metilación del gen VDR, género, perfil metabólico, estrés oxidativo e inflamación en adolescentes.
- Authors
Lacerda de Lucena, Lavoisiana; Sérgio Silva, Alexandre; Ferreira do Nascimento, Rayner Anderson; Camati Persuhn, Darlene; Ramos Neves, Juliana Padilha; de Carvalho Costa, Maria José; Marques Queiroz, Dayanna Joyce; Formiga Cavalcanti de Lima, Rafaela Lira; Ataíde Lima, Raquel Patrícia; de Paiva, Maria Paula; Paulo de Oliveira, Naila Francis; Rodrigues Gonçalves, Maria da Conceição; Silva, Alexandre Sérgio; Nascimento, Rayner Anderson Ferreira do; Persuhn, Darlene Camati; Neves, Juliana Padilha Ramos; Costa, Maria José Carvalho; Queiroz, Dayana Joyce Marques; de Lima, Rafaela Lira Formiga Covalcanti; Ataíde de Lima, Raquel Patrícia
- Abstract
<bold>Introduction: </bold>Background: the biological activity of vitamin D depends on the activity of its receptor or VDR. On the other hand, the activity of this receptor is influenced by its state of methylation. The objective of this study was to verify if the BsmI polymorphism of the VDR gene influences its methylation profile in adolescents. Secondly, it was to verify if the status of some metabolic factors (oxidative stress, inflammation, lipid profile, and glycemia) in the serum, and gender-adjusted vitamin D levels are independent factors with an influence on the VDR methylation profile. Methods and results: the study included 198 adolescents of both sexes, aged 15-19 years, who underwent testing for VDR gene methylation polymorphisms, serum vitamin D levels, and metabolic, oxidative stress, and systemic inflammation markers. It was observed that the BB genotype was less methylated than the other groups (26.1 % versus 30.3 %, and 29.3 % for Bb and bb, respectively), although without statistical differences between them. The odds ratio indicated a protection of 13 % (partially methylated) for vitamin D status, while alpha glycols increased the risk ratio (of being partially methylated) by 3 %. MDA was protective at a 28 % chance of risk that adolescents with higher levels of lipid peroxidation would be hypomethylated. Conclusion: we conclude that the methylation profile of the VDR gene is not influenced by the different BsmI polymorphism genotypes, and that serum vitamin D and serum markers of oxidative stress and inflammation can modulate this profile.
- Subjects
INFLAMMATION prevention; INFLAMMATION; CELL receptors; METABOLISM; GENETIC polymorphisms; SEX distribution; OXIDATIVE stress; METHYLATION
- Publication
Nutrición Hospitalaria, 2021, Vol 38, Issue 5, p911
- ISSN
0212-1611
- Publication type
journal article
- DOI
10.20960/nh.03383