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- Title
Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions.
- Authors
Fischer, Sandra; Lichtenthaeler, Chiara; Stepanenko, Anastasiya; Heyl, Florian; Maticzka, Daniel; Kemmerer, Katrin; Klostermann, Melina; Backofen, Rolf; Zarnack, Kathi; Weigand, Julia E.
- Abstract
HnRNPs are ubiquitously expressed RNA-binding proteins, tightly controlling posttranscriptional gene regulation. Consequently, hnRNP networks are essential for cellular homeostasis and their dysregulation is associated with cancer and other diseases. However, the physiological function of hnRNPs in non-cancerous cell systems are poorly understood. We analyzed the importance of HNRNPDL in endothelial cell functions. Knockdown of HNRNPDL led to impaired proliferation, migration and sprouting of spheroids. Transcriptome analysis identified cyclin D1 (CCND1) and tropomyosin 4 (TPM4) as targets of HNRNPDL, reflecting the phenotypic changes after knockdown. Our findings underline the importance of HNRNPDL for the homeostasis of physiological processes in endothelial cells.
- Subjects
CELL physiology; ENDOTHELIAL cells; SYNCRIP protein; NUCLEOPROTEINS; RNA-binding proteins; GENETIC regulation; PHENOTYPIC plasticity
- Publication
Biological Chemistry, 2024, Vol 405, Issue 4, p229
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/hsz-2023-0254