We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Extracellular adenine nucleotides inhibit the release of major monocyte recruiters by human monocyte-derived dendritic cells
- Authors
Horckmans, Michael; Marcet, Brice; Marteau, Frédéric; Bulté, Frédéric; Maho, Arielle; Parmentier, Marc; Boeynaems, Jean-Marie; Communi, Didier
- Abstract
Abstract: Extracellular ATP is known to affect the maturation of monocyte-derived dendritic cells mainly by regulation of cytokines and costimulatory molecules. The present study describes the inhibition of MCP-1 (CCL2) and MIP-1α (CCL3) release by human monocyte-derived dendritic cells in response to adenine nucleotides. Our pharmacological data support the involvement of P2Y11 and P2Y1 purinergic receptors in the downregulation of these major monocyte recruiters. Migration assays have demonstrated that supernatants of dendritic cells treated with adenine nucleotides or anti-MCP-1/MIP-1α blocking antibodies display a strongly reduced capacity to attract monocytes and immature dendritic cells.
- Subjects
ADENINE; NUCLEOTIDES; MONOCYTES; DENDRITIC cells
- Publication
FEBS Letters, 2006, Vol 580, Issue 3, p747
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.12.091