We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Pyogenic liver abscess in patients with inflammatory bowel disease: a nationwide cohort study.
- Authors
Lin, Jiun ‐ Nong; Lin, Cheng ‐ Li; Lin, Ming ‐ Chia; Lai, Chung ‐ Hsu; Lin, Hsi ‐ Hsun; Kao, Chia ‐ Hung
- Abstract
Background & Aims: Pyogenic liver abscess (PLA) is a rare and severe extraintestinal complication in patients with inflammatory bowel disease (IBD). However, the incidence of PLA in patients with IBD remains unknown. Methods: A nationwide cohort study was conducted by analysing data from the National Health Insurance Research Database in Taiwan. Patients with IBD (N = 11 504) from 2000 to 2010 and control participants without IBD (N = 46 016) were included in this study. We analysed the risks of PLA by using competing-risks (death) regression models. Results: The incidence of PLA was higher in the IBD cohort than in the control cohort (6.72 vs 4.06 per 10 000 person-years), with an adjusted subhazard ratio (SHR) of 1.46 (95% confidence interval [CI], 1.01-2.12). Patients with IBD who required two or more hospitalizations per year and underwent laparotomy had an increased risk of PLA. Patients with ulcerative colitis were more likely to develop PLA than were those with Crohn's disease (incidence, 8.56 vs 5.45 per 10 000 person-years; adjusted SHR, 1.65 vs 1.32). Among the IBD cohort, age and gender did not affect PLA risk. Patients with diabetes mellitus or percutaneous aspiration of the gallbladder and biliary tract and who underwent endoscopic insertion of a biliary drainage tube exhibited a significantly increased risk of PLA. Conclusions: Patients with IBD exhibited an increased risk of developing PLA, particularly those with ulcerative colitis. Knowledge of the expected frequency and potential risk for this severe extraintestinal infection may minimize the serious consequences.
- Subjects
INFLAMMATORY bowel diseases; PYOGENIC liver abscess; LIVER abscesses; BILIARY tract; INTESTINES
- Publication
Liver International, 2016, Vol 36, Issue 1, p136
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/liv.12875