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- Title
Neutrophil-to-lymphocyte ratio predicts mortality in patients listed for liver transplantation.
- Authors
Leithead, Joanna A.; Rajoriya, Neil; Gunson, Bridget K.; Ferguson, James W.
- Abstract
Background & Aims In the absence of overt infection, the systemic inflammatory response is increasingly recognised as a pathogenetic factor in the circulatory dysfunction of advanced cirrhosis. Our aim was to determine whether the neutrophil-to-lymphocyte ratio, a marker of systemic inflammation, is predictive of mortality in patients with end-stage cirrhosis listed for liver transplantation. Methods A single centre study of 570 patients listed for first elective single-organ liver transplantation January 2007-June 2011. Results The median listing neutrophil-to-lymphocyte ratio was 2.9 ( IQR 1.9-4.7). Neutrophil-to-lymphocyte ratio demonstrated a positive correlation with listing serum bilirubin ( P < 0.001), negative correlation with serum sodium ( P < 0.001), and positive correlation with the MELD score ( P < 0.001). Neutrophil-to-lymphocyte ratio increased with increasing severity of ascites ( P < 0.001). A higher neutrophil count ( P < 0.001) and lower lymphocyte count ( P = 0.001) were predictors of wait-list death. In a multivariate competing risk Cox model, neutrophil-to-lymphocyte ratio remained independently associated with mortality ( HR 1.10; 95% CI 1.05-1.15, P < 0.001). The proportion of patients with a neutrophil-to-lymphocyte ratio <2, 2-4.9, and ≥5 who had died by 3 months of listing was 3%, 13.8% and 37.3% respectively ( P < 0.001). After adjusting for MELD, increasing increments of neutrophil-to-lymphocyte ratio were predictive of death by 3 months ( P = 0.043). Conclusions The blood neutrophil-to-lymphocyte ratio, a simple and readily available marker of systemic inflammation, is an independent predictor of mortality in patients with liver failure listed for liver transplantation.
- Subjects
NEUTROPHILS; LYMPHOCYTE count; DEATH forecasting; CIRRHOSIS of the liver; BIOMARKERS; PATIENTS
- Publication
Liver International, 2015, Vol 35, Issue 2, p502
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/liv.12688