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- Title
Relationship between temporal changes of endometrial blood flow impedance during natural and hormone replacement cycles and prediction of pregnancy during vitrified‐warmed embryo transfer.
- Authors
Ota, Kuniaki; Shiraishi, Satoru; Takahashi, Toshifumi
- Abstract
Aim: This study aimed to examine the relationship between the temporal changes in endometrial blood flow impedance during natural and hormone replacement therapy (HRT) cycles and clinical outcomes of vitrified‐warmed embryo transfer (ET). Methods: This retrospective observational cohort study included 60 women, 28 with natural, and 32 with HRT cycles, who underwent vitrified‐warmed ET. Uterine radial artery resistance index (RA‐RI) was measured during the natural and HRT cycles at the following time points: early follicular phase, day of the human chorionic gonadotropin injection during a natural cycle or day of progesterone administration during an HRT cycle, and day of ET. Results: The clinical pregnancy rates of the natural and HRT cycles were 32.1% and 34.4%, respectively. The RA‐RI at the early follicular phase was significantly lower in the pregnant group than in the nonpregnant group with natural but not HRT cycles (p = 0.04). The odds ratio for pregnancy was 0.70 (95% confidence interval [CI], 0.52–0.95) when the RA‐RI value at the early follicular phase was increased by 0.01 in the natural cycle. With the natural cycle, the area under the receiver‐operating characteristic curves for the RA‐RI at the early follicular phase with a threshold of 0.68 was 0.75 (95% CI, 0.57–0.93), and the positive and negative predictive values were 0.53 (95% CI, 0.37–0.59) and 0.92 (0.74–0.99), respectively. Conclusion: RA‐RI at the early follicular phase might be an effective and useful tool for deciding between natural or HRT cycles for vitrified‐warmed ET.
- Subjects
THERAPEUTICS; HORMONES; SCIENTIFIC observation; INJECTIONS; PROGESTERONE; CONFIDENCE intervals; PREDICTIVE tests; MENSTRUAL cycle; RETROSPECTIVE studies; PREGNANCY outcomes; EMBRYO transfer; UTERUS; RADIAL artery; DESCRIPTIVE statistics; ODDS ratio; RECEIVER operating characteristic curves; ENDOMETRIUM; LONGITUDINAL method; CHORIONIC gonadotropins
- Publication
Journal of Obstetrics & Gynaecology Research, 2021, Vol 47, Issue 3, p1052
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.14637