We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Chiral separation of benzothiazole derivatives of amino acids using capillary zone electrophoresis.
- Authors
Nováková, Zuzana; Pejchal, Vladimír; Fischer, Jan; Česla, Petr
- Abstract
A method for the separation of enantiomers of leucine and phenylalanine benzothiazole derivatives as potential antimicrobial agents was developed using capillary zone electrophoresis with a dual cyclodextrin (CD) system. The best resolution of enantiomers was achieved in 100 mmol/L phosphate background electrolyte (pH 3.5) with the dual CD system consisting of 10 mmol/L of β-CD with 10 mmol/L of 2-hydroxypropyl-β-cyclodextrin for leucine derivative and 10 mmol/L of 2-hydroxypropyl-γ-cyclodextrin for phenylalanine derivative, respectively. Under the optimal conditions, the highest enantioresolution of 1.25 was achieved in a noncoated-fused silica capillary at 17°C and 24 kV applied voltage.
- Subjects
CHIRALITY; BENZOTHIAZOLE; AMINO acids; ELECTROPHORESIS; CYCLODEXTRINS
- Publication
Journal of Separation Science, 2017, Vol 40, Issue 3, p798
- ISSN
1615-9306
- Publication type
Article
- DOI
10.1002/jssc.201600689