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- Title
Magnetic Nanoparticles: Hierarchically Structured Magnetic Nanoconstructs with Enhanced Relaxivity and Cooperative Tumor Accumulation (Adv. Funct. Mater. 29/2014).
- Authors
Gizzatov, Ayrat; Key, Jaehong; Aryal, Santosh; Ananta, Jeyarama; Cervadoro, Antonio; Palange, Anna Lisa; Fasano, Matteo; Stigliano, Cinzia; Zhong, Meng; Di Mascolo, Daniele; Guven, Adem; Chiavazzo, Eliodoro; Asinari, Pietro; Liu, Xuewu; Ferrari, Mauro; Wilson, Lon J.; Decuzzi, Paolo
- Abstract
Nanoconstructs are realized by P. Decuzzi and co‐workers by confining ultra‐small (5 nm) superparamagnetic iron oxide nanoparticles (USPIOs) within two different mesoporous structures (silicon and polymers). On page 4584, they exhibit transversal relaxivities up to around 10 times higher than conventional USPIOs and, under external magnetic fields, collectively cooperate to amplify tumor accumulation in mice to provide an MRI contrast enhancement at much smaller doses of iron as compared to current practice.
- Subjects
IRON oxide nanoparticles; MAGNETIC resonance; MEDICINE; NANOMEDICINE; MATERIALS science
- Publication
Advanced Functional Materials, 2014, Vol 24, Issue 29, p4562
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.201470189