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- Title
Multifunctional Graphene-PEDOT Microelectrodes for On-Chip Manipulation of Human Mesenchymal Stem Cells.
- Authors
Hsiao, Yu‐Sheng; Kuo, Chiung‐Wen; Chen, Peilin
- Abstract
All-solution-processed multifunctional organic bioelectronics composed of reduced graphene oxide (rGO) and dexamethasone 21-phosphate disodium salt (DEX)-loaded poly(3,4-ethylenedioxythiophene) (PEDOT) microelectrode arrays on indium tin oxide glass are reported. They can be used to manipulate the differentiation of human mesenchymal stem cells (hMSCs). In the devices, the rGO material functions as an adhesive coating to promote the adhesion and alignment of hMSC cells and to accelerate their osteogenic differentiation. The poly( L-lysine- graft-ethylene glycol) (PLL- g-PEG)-coated PEDOT electrodes serve as electroactive drug-releasing electrodes. In addition, the corresponding three-zone parallel devices operate as efficient drug-releasing components through spatial-temporal control of the release of the drug DEX from the PEDOT matrix. Such devices can be used for long-term cell culturing and controlled differentiation of hMSCs through electrical stimulation.
- Subjects
GRAPHENE; MICROELECTRODES; MESENCHYMAL stem cells; BIOELECTRONICS; INDIUM tin oxide; CELL adhesion; CELL differentiation
- Publication
Advanced Functional Materials, 2014, Vol 23, Issue 37, p4649
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.201203631