We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
MIM: a multifunctional scaffold protein.
- Authors
Machesky, Laura M.; Johnston, Simon A.
- Abstract
The protein “missing in metastasis”, known as MIM, has been characterised as an actin-binding scaffold protein that may be involved in cancer metastasis. In this paper, we summarise the literature surrounding the role of MIM in actin and membrane dynamics and in signalling to transcription via the sonic hedgehog pathway. MIM is postulated to have many potential activities, including a BAR-like domain termed the IMD (IRS-MIM domain), which can interact with membranes to induce membrane deformation and also with actin and the small GTPase Rac. How this multifunctional protein and its close relative ABBA-1 regulate cellular behaviour is still very much an open question.
- Subjects
METASTASIS; ACTIN; CYTOSKELETON; HEDGEHOG signaling proteins; CANCER cells; HOMOLOGY (Biology); CANCER invasiveness
- Publication
Journal of Molecular Medicine, 2007, Vol 85, Issue 6, p569
- ISSN
0946-2716
- Publication type
Article
- DOI
10.1007/s00109-007-0207-0