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- Title
Postsynaptic scaffold proteins at non-synaptic sites.
- Authors
Kneussel, Matthias
- Abstract
Synapse-associated proteins that are located at the postsynaptic density (PSD) have recently been shown to have a structural role at non-synaptic locations. Here, they act as adaptor proteins between neurotransmitter receptors and the microtubule- or microfilament-based motor-protein complexes that are responsible for transport to the PSD. The use of a common set of proteins that contain multiple domains for protein-protein interactions as both intracellular transport adaptors and synaptic scaffold proteins might contribute to the transport specificity and postsynaptic integration of receptors that underlie synapse formation and plasticity.
- Subjects
NEURAL transmission; NERVES; PROTEINS; BIOMOLECULES; NEUROTRANSMITTERS; NEUROCHEMISTRY
- Publication
EMBO Reports, 2005, Vol 6, Issue 1, p22
- ISSN
1469-221X
- Publication type
Article
- DOI
10.1038/sj.embor.7400319