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- Title
Lack of Association between Postoperative Pancreatitis and Other Postoperative Complications Following Pancreaticoduodenectomy.
- Authors
Yoo, Daegwang; Park, Seo Young; Hwang, Dae Wook; Lee, Jae Hoon; Song, Ki Byung; Lee, Woohyung; Park, Yejong; Jun, Eunsung; Kim, Song Cheol; Biebl, Matthias
- Abstract
Background: Prediction of post-pancreaticoduodenectomy (PD) morbidity is difficult, especially in the early postoperative period when CT (Computed Tomography) scans are not available. Elevated serum amylase and lipase in postoperative day 0 or 1 may be used to define postoperative acute pancreatitis (POAP), but the existing literature does not agree on whether POAP is significantly associated with postoperative pancreatic fistula (POPF). Methods: We analyzed the data obtained from a previously published randomized controlled trial. POAP was defined as elevations in serum amylase above 110 U/L on postoperative day 0 or 1. Clinically relevant POAP (CR-POAP) was defined as elevations in C-reactive protein level (CRP) on postoperative day 2 in those with POAP. Postoperative complications including severe complications (Clavien–Dindo ≥ IIIa), POPF, and clinically relevant POPF (CR-POPF) were analyzed. Results: In 246 patients, POAP did not show significant associations with total postoperative complications (odds ratio (OR) 0.697; 95% CI, 0.360–1.313; p = 0.271), severe complications (OR 0.647; 95% CI, 0.258–1.747; p = 0.367), and CR-POPF (OR 0.998; 95% CI, 0.310–3.886; p = 0.998) in multivariable analysis. Conclusions: In patients undergoing PD, POAP was not significantly associated with postoperative complications including POPF. Caution should be taken when using POAP as a predictor of POPF.
- Subjects
PANCREATICODUODENECTOMY; SURGICAL complications; PANCREATITIS; PANCREATIC fistula; POSTOPERATIVE period; C-reactive protein
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 6, p1179
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10061179