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- Title
Growth Differentiation Factor 15: A Biomarker with High Clinical Potential in the Evaluation of Kidney Transplant Candidates.
- Authors
de Cos Gomez, Marina; Benito Hernandez, Adalberto; Garcia Unzueta, Maria Teresa; Mazon Ruiz, Jaime; Lopez del Moral Cuesta, Covadonga; Perez Canga, Jose Luis; San Segundo Arribas, David; Valero San Cecilio, Rosalia; Ruiz San Millan, Juan Carlos; Rodrigo Calabia, Emilio
- Abstract
Kidney transplantation implies a significant improvement in patient survival. Nevertheless, early mortality after transplant remains high. Growth differentiation factor 15 (GDF-15) is a novel biomarker under study as a mortality predictor in multiple scenarios. The aim of this study is to assess the utility of GDF-15 to predict survival in kidney transplant candidates. For this purpose, 395 kidney transplant recipients with pretransplant stored serum samples were included. The median GDF-15 was 5331.3 (50.49–16242.3) pg/mL. After a mean of 90.6 ± 41.5 months of follow-up, 82 (20.8%) patients died. Patients with higher GDF-15 levels (high risk tertile) had a doubled risk of mortality after adjustment by clinical characteristics (p = 0.009). After adjustment by EPTS (Estimated Post Transplant Survival score) the association remained significant for medium hazards ratios (HR) 3.24 95%CI (1.2–8.8), p = 0.021 and high risk tertiles HR 4.3 95%CI (1.65–11.54), p = 0.003. GDF-15 improved the prognostic accuracy of EPTS at 1-year (ΔAUC = 0.09, p = 0.039) and 3-year mortality (ΔAUC = 0.11, p = 0.036). Our study suggests an independent association between higher GDF-15 levels and mortality after kidney transplant, adding accuracy to the EPTS score, an established risk prediction model currently used in kidney transplant candidates.
- Subjects
KIDNEY transplantation; BIOMARKERS; PREDICTION models; TRANSPLANTATION of organs, tissues, etc.; GROWTH differentiation factors
- Publication
Journal of Clinical Medicine, 2020, Vol 9, Issue 12, p4112
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm9124112