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- Title
Egg OIT in clinical practice (SEICAP II): Maintenance patterns and desensitization state after normalizing the diet.
- Authors
Eigenmann, Philippe; Martín‐Muñoz, María Flora; Belver, María Teresa; Echeverría, Luis; Alonso Lebrero, Elena; Zapatero, Lidia; Fuentes Aparicio, Victoria; Piquer Gibert, Mónica; Plaza Martín, Ana María; Muñoz, Candelaria; Martorell‐Calatayud, Cristina; Martorell‐Aragonés, Antonio; Blasco, Cristina; Vilá, Blanca; Gómez, Catalina; Nevot, Santiago; García Martín, Juan Miguel; Madero, Rosario
- Abstract
Background: It is unknown which are the most suitable maintenance pattern and egg consumption to maintain the desensitization state after ending the oral immunotherapy (OIT). This multicenter, randomized, controlled trial compared two OIT maintenance patterns with pasteurized egg white (PEW), evaluating the egg consumption effect on the desensitization state after ending the OIT. Methods: One hundred and one children with confirmed egg allergy were randomized: 25 to an egg‐free diet (CG) and 76 to an OIT year with PEW and two maintenance patterns, 38 patients to daily 3.3 g proteins (AG) and 38 to every two days (BG). PEW challenge (DBPCFC), adverse reactions, and immune markers were assessed at baseline, at the end of the OIT, and at 6 and 12 months later on ad libitum egg consumption (T0, T12, T18, and T24). A questionnaire evaluated the egg consumption at T18. Results: At T12, 64 of 76 (84.21%) OIT patients had reached total desensitization (32 AG and 32 BG) vs 4 of 25 (16.00%) CG who passed the PEW DBPCFC. Thirty (93.75%) AG vs 25 (78.12%) BG patients completed an OIT year. At T18, 27 of 29 (93.1%) AG vs 20 of 24 (83.3%) BG passed the PEW DBPCFC, 96% consuming at least two egg servings/week. At T24, 97.43% OIT patients passed the challenge. Most patients had adverse reactions, more frequent in the BG patients; frequency and severity of reactions decreased through the study. PEW skin prick test wheal and sIgE antibody serum levels similarly decreased in AG or BG, but AG patients had greater increase in PEW sIgG4 (P < 0.05). Conclusions: Daily OIT maintenance achieves better adherence, effectiveness, and safety. Two egg servings/week ensure maintained desensitization after the end of an OIT year.
- Subjects
EGGS; G proteins; BIOMARKERS; DIET
- Publication
Pediatric Allergy & Immunology, 2019, Vol 30, Issue 2, p214
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.13002