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- Title
High expression of tight junction protein 1 as a predictive biomarker for bladder cancer grade and staging.
- Authors
Lee, Yi-Chen; Tsai, Kuo-Wang; Liao, Jia-Bin; Kuo, Wei-Ting; Chang, Yu-Chan; Yang, Yi-Fang
- Abstract
Tight junction proteins 1–3 (TJP1–3) are components of tight junctions that can link transmembrane proteins to the actin cytoskeleton, and their incidence directly correlates to metastasis. However, the role of the TJP family in bladder cancer has not been adequately evaluated. In this study, we evaluated the genetic changes, mRNA and protein expressions of the target genes of the TJP family in bladder cancer patients using online database and immunohistochemistry, respectively. We found that TJP1 was amplified in bladder cancer tissue and that the protein expression levels were significantly associated with age (p = 0.03), grade (p = 0.007), and stage (p = 0.011). We also examined the correlation between TJP1 and other high-frequency mutation genes using TIMER. TJP1 mRNA levels were positively correlated with TTN and RYR3 mRNA levels in bladder cancer tissue. Taken together, TJP1 expression is associated with poor clinical outcomes in patients with bladder cancer and can be a useful predictive biomarker for bladder cancer staging.
- Subjects
BLADDER cancer; CLAUDINS; TUMOR classification; MEMBRANE proteins; BIOMARKERS; CYTOSKELETON
- Publication
Scientific Reports, 2022, Vol 12, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-022-05631-y