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- Title
Pancreatic Beta Cell Function in Infants Varies by Maternal Weight.
- Authors
Staimez, Lisa R.; Dutta, Anubrati; Beyh, Yara S.; Gupta, Ruby; Noule, Hari Krishna; Sapna, Vyakaranam; Deepa, Kothapally; Stein, Aryeh D.; Narayan, K.M. Venkat; Prabhakaran, Dorairaj; Kalpana, Basany; Prabhakaran, Poornima
- Abstract
The Asian Indian Beta Cell function (ABCs) in Infants Study examined the associations of maternal weight on infant pancreatic beta cell function across 7 months postpartum. Pregnant women aged 18–35 years were recruited in Hyderabad, India. Women were classified by first trimester weight as underweight (UW), BMI < 18.5 kg/m2; normal weight (NW), BMI 18.5–22.9 kg/m2; or overweight (OW), BMI 23.0 through <28.5 kg/m2. At age > 7 months, infants had an oral glucose tolerance test (OGTT, 1.75 g glucose/kg bodyweight) following a 3 h fast. Infant blood samples were assayed for C-peptide and glucose. Infant beta cell function (HOMA2-B; disposition index, DI) and insulin resistance (HOMA2-IR) were compared across maternal weight groups. Mothers (UW n = 63; NW n = 43; OW n = 29) had similar age at delivery and second trimester 50 g glucose challenge test results. Cord HOMA2-B values were 51% greater for IUW (83.5, SD 55.2) and 44% greater for IOW (79.9, SD 60.8) vs. INW (55.4, SD 51.5), forming a U-shaped relationship between maternal weight and HOMA2-B. No qualitative differences in HOMA2-IR were found at birth. However, at 7 months postpartum, HOMA2-IR changed most within IUW (−64% median reduction) and changed the least in IOW (−7% median reduction). At seven months postpartum, DI was higher in IUW vs. the other groups (geometric mean IUW 1.9 SD 2.5; INW 1.3 SD 2.6 or vs. IOW mean 1.2 SD 3.7), reflecting a +49% difference in DI. Evidence from this study illustrates adaptations in the pancreatic functional response of infants associated with the maternal nutritional environment.
- Subjects
HYDERABAD (India); PANCREATIC beta cells; BETA functions; CELL physiology; INFANTS; GLUCOSE tolerance tests; WEIGHT in infancy; GESTATIONAL diabetes
- Publication
Metabolites (2218-1989), 2024, Vol 14, Issue 4, p208
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo14040208