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- Title
Editorial: HIV-Associated Immune Activation and Persistent Inflammation.
- Authors
Hoenigl, Martin; Kessler, Harald H.; Gianella, Sara
- Abstract
While modern antiretroviral therapy (ART) improves health, prolongs survival, and reduces HIV transmission, successfully treated HIV infection remains associated with persistent inflammation and immune dysfunction ([1]-[3]). The current Research Topic includes in total 11 high-quality manuscripts, ranging from host-response activation during HIV infection (Tjitro et al.), the role of toll-like receptor (TLR)-10 ligand during HIV replication (Henrick et al.), microRNA-19b as a regulator of CD8 SP + sp T cell functions during HIV infection (Yin et al.), to potentiating the immune response via PD1 checkpoint inhibition (Filaci et al.). Another study included in this supplement elucidated the role of the immunomodulatory carbohydrate-binding protein Galectin-9 in HIV transcription and in maintaining chronic immune activation during ART-suppressed HIV infection (Colomb et al.). Poly-ICLC can activate immune cells and induce HIV replication in pre-clinical experiments, but this study for the first time investigated its effect in disrupting HIV latency I in vivo i while simultaneously enhancing innate immune responses.
- Subjects
T helper cells; HIV infections; CARBOHYDRATE-binding proteins; BACTERIAL cell walls; HIV infection transmission
- Publication
Frontiers in Immunology, 2019, Vol 10, p1
- ISSN
1664-3224
- Publication type
Editorial
- DOI
10.3389/fimmu.2019.02858